The primary focus of the lab is to understand basic cell biological processes used by light-sensitive photoreceptor neurons of the retina and how these processes are disrupted during inherited retinal degeneration. Specifically, we study how signaling proteins are transported and delivered within retinal photoreceptors to ensure these neurons properly develop and function. Research will involve using molecular and cellular tools and in vivo models. The successful job candidates will provide technical support for the lab. Duties will include preparing protein, RNA, and DNA samples; molecular cloning; genotyping transgenic mouse line; sectioning mouse retinal tissue; analyzing protein and gene expression by immunoblotting, quantitative PCR, and immunohistochemistry. Duties will also include general lab maintenance such as ordering supplies, cleaning and organizing the laboratory as needed. |